# ACTH (Corticotropin)

Canonical source: https://retacompare.com/encyclopedia/acth

Binds melanocortin-2 receptor (MC2R) on adrenal cortex, stimulating cortisol synthesis.

Reference facts

Also known asAdrenocorticotropic Hormone, Acthar GelCategoryHormonal & PituitaryMechanism of actionBinds melanocortin-2 receptor (MC2R) on adrenal cortex, stimulating cortisol synthesis.TargetsMC2RIndications under research or approvedInfantile spasms (West syndrome), Multiple sclerosis exacerbations, Diagnostic testingRegulatory status (reference entry)FDA-approved (Acthar Gel)Half-life~15 minutesSequenceSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEFSequence notes39-residue peptide hormone produced by anterior pituitary corticotrophs.Molecular weight (Da)4541First reported1955
    Primary References

Acthar Gel FDA label


    Explore research articles about ACTH (Corticotropin)


    This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.

## Sources

- Acthar Gel FDA label: https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/008372s073lbl.pdf