Mimics the N-terminus of SNAP-25 and competes for SNARE complex assembly, dampening neurotransmitter release at the neuromuscular junction (proposed wrinkle-reduction mechanism).
Reference facts
- Also known as
- Acetyl Hexapeptide-3, Acetyl Hexapeptide-8
- Category
- Cosmetic & Skin
- Mechanism of action
- Mimics the N-terminus of SNAP-25 and competes for SNARE complex assembly, dampening neurotransmitter release at the neuromuscular junction (proposed wrinkle-reduction mechanism).
- Targets
- SNARE complex (in vitro)
- Indications under research or approved
- Cosmetic anti-wrinkle topical formulations
- Regulatory status (reference entry)
- Cosmetic ingredient; not FDA-approved as drug
- Half-life
- Minutes (topical, local action)
- Sequence
- EEMQRR
- Sequence notes
- Hexapeptide Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2; mimics the N-terminus of SNAP-25.
- Molecular weight (Da)
- 889
- Originator / sponsor
- Lipotec / Lubrizol
- First reported
- 2002
Primary References
Explore research articles about Argireline
This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.