# Argireline

Canonical source: https://retacompare.com/encyclopedia/argireline

Mimics the N-terminus of SNAP-25 and competes for SNARE complex assembly, dampening neurotransmitter release at the neuromuscular junction (proposed wrinkle-reduction mechanism).

Reference facts

Also known asAcetyl Hexapeptide-3, Acetyl Hexapeptide-8CategoryCosmetic & SkinMechanism of actionMimics the N-terminus of SNAP-25 and competes for SNARE complex assembly, dampening neurotransmitter release at the neuromuscular junction (proposed wrinkle-reduction mechanism).TargetsSNARE complex (in vitro)Indications under research or approvedCosmetic anti-wrinkle topical formulationsRegulatory status (reference entry)Cosmetic ingredient; not FDA-approved as drugHalf-lifeMinutes (topical, local action)SequenceEEMQRRSequence notesHexapeptide Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2; mimics the N-terminus of SNAP-25.Molecular weight (Da)889Originator / sponsorLipotec / LubrizolFirst reported2002
    Primary References

Blanes-Mira et al., Int J Cosmet Sci 2002 (Argireline)


    Explore research articles about Argireline


    This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.

## Sources

- Blanes-Mira et al., Int J Cosmet Sci 2002 (Argireline): https://pubmed.ncbi.nlm.nih.gov/18494889/