# B-type Natriuretic Peptide (BNP)

Canonical source: https://retacompare.com/encyclopedia/bnp

Activates NPR-A, elevating cGMP. Vasodilation, natriuresis, suppression of RAAS.

Reference facts

Also known asNesiritide, NatrecorCategoryCardiovascular & NatriureticMechanism of actionActivates NPR-A, elevating cGMP. Vasodilation, natriuresis, suppression of RAAS.TargetsNPR-AIndications under research or approvedAcute decompensated heart failure (Nesiritide; withdrawn 2018 in US for commercial reasons after ASCEND-HF efficacy concerns)Regulatory status (reference entry)Withdrawn in US (2018)Half-life~20 minutes (recombinant Nesiritide)SequenceSPKMVQGSGCFGRKMDRISSSSGLGCKVLRRHSequence notes32-residue peptide with disulfide bridge Cys10-Cys26.Molecular weight (Da)3464First reported1988
    Primary References

ASCEND-HF, NEJM 2011


    Explore research articles about B-type Natriuretic Peptide (BNP)


    This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.

## Sources

- ASCEND-HF, NEJM 2011: https://www.nejm.org/doi/full/10.1056/NEJMoa1100171