Historically considered inert; emerging evidence suggests binding to a putative GPCR with renal and microvascular protective effects.
Reference facts
- Also known as
- Connecting Peptide
- Category
- Hormonal & Pituitary
- Mechanism of action
- Historically considered inert; emerging evidence suggests binding to a putative GPCR with renal and microvascular protective effects.
- Targets
- Putative GPCR
- Indications under research or approved
- Diagnostic marker of endogenous insulin secretion; research in diabetic neuropathy
- Regulatory status (reference entry)
- Diagnostic use; not FDA-approved as therapeutic
- Half-life
- ~30 minutes
- Sequence
- EAEDLQVGQVELGGGPGAGSLQPLALEGSLQ
- Sequence notes
- 31-residue peptide cleaved from proinsulin during insulin maturation. Released in equimolar amounts with insulin.
- Molecular weight (Da)
- 3020
- First reported
- 1967
Primary References
Explore research articles about C-peptide
This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.