Cationic β-sheet peptide that disrupts microbial membranes and modulates intestinal microbiota.
Reference facts
- Also known as
- Human α-Defensin 5, DEFA5
- Category
- Antimicrobial
- Mechanism of action
- Cationic β-sheet peptide that disrupts microbial membranes and modulates intestinal microbiota.
- Targets
- Microbial membranes, Intestinal innate immunity
- Indications under research or approved
- Research
- Regulatory status (reference entry)
- Not FDA-approved
- Half-life
- Minutes systemically; concentrated in gut
- Sequence
- ATCYCRTGRCATRESLSGVCEISGRLYRLCCR
- Sequence notes
- 32-residue α-defensin from human Paneth cells; three intramolecular disulfide bonds.
- Molecular weight (Da)
- 3582
- PDB accession
- 1ZMP
- First reported
- 1992
Primary References
Explore research articles about Defensin HD-5
This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.