# Defensin HD-5

Canonical source: https://retacompare.com/encyclopedia/defensin-hd5

Cationic β-sheet peptide that disrupts microbial membranes and modulates intestinal microbiota.

Reference facts

Also known asHuman α-Defensin 5, DEFA5CategoryAntimicrobialMechanism of actionCationic β-sheet peptide that disrupts microbial membranes and modulates intestinal microbiota.TargetsMicrobial membranes, Intestinal innate immunityIndications under research or approvedResearchRegulatory status (reference entry)Not FDA-approvedHalf-lifeMinutes systemically; concentrated in gutSequenceATCYCRTGRCATRESLSGVCEISGRLYRLCCRSequence notes32-residue α-defensin from human Paneth cells; three intramolecular disulfide bonds.Molecular weight (Da)3582PDB accession1ZMPFirst reported1992
    Primary References

Selsted & Ouellette, Nat Immunol 2005 (Defensins)


    Explore research articles about Defensin HD-5


    This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.

## Sources

- Selsted & Ouellette, Nat Immunol 2005 (Defensins): https://pubmed.ncbi.nlm.nih.gov/15962001/