Selective V2 receptor agonist (renal antidiuresis) with minimal pressor effect; releases von Willebrand factor and Factor VIII from endothelium.
Reference facts
- Also known as
- DDAVP, Stimate, 1-deamino-8-D-arginine vasopressin
- Category
- Hormonal & Pituitary
- Mechanism of action
- Selective V2 receptor agonist (renal antidiuresis) with minimal pressor effect; releases von Willebrand factor and Factor VIII from endothelium.
- Targets
- V2R
- Indications under research or approved
- Central diabetes insipidus, Nocturnal enuresis, Mild hemophilia A and von Willebrand disease
- Regulatory status (reference entry)
- FDA-approved (1978)
- Half-life
- ~3 hours
- Sequence notes
- Synthetic AVP analog: 1-desamino-cysteine and D-Arg at position 8, retaining Cys1-Cys6 disulfide.
- Molecular weight (Da)
- 1069
- First reported
- 1967
Primary References
Explore research articles about Desmopressin
This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.