# Desmopressin

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Selective V2 receptor agonist (renal antidiuresis) with minimal pressor effect; releases von Willebrand factor and Factor VIII from endothelium.

Reference facts

Also known asDDAVP, Stimate, 1-deamino-8-D-arginine vasopressinCategoryHormonal & PituitaryMechanism of actionSelective V2 receptor agonist (renal antidiuresis) with minimal pressor effect; releases von Willebrand factor and Factor VIII from endothelium.TargetsV2RIndications under research or approvedCentral diabetes insipidus, Nocturnal enuresis, Mild hemophilia A and von Willebrand diseaseRegulatory status (reference entry)FDA-approved (1978)Half-life~3 hoursSequence notesSynthetic AVP analog: 1-desamino-cysteine and D-Arg at position 8, retaining Cys1-Cys6 disulfide.Molecular weight (Da)1069First reported1967
    Primary References

Robertson et al., NEJM 1973 (DDAVP)


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    This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.

## Sources

- Robertson et al., NEJM 1973 (DDAVP): https://pubmed.ncbi.nlm.nih.gov/4350777/