Hepatocyte growth factor (HGF) / c-Met receptor agonist that promotes synaptogenesis and dendritic spine density in hippocampal neurons.
Reference facts
- Also known as
- PNB-0408, N-hexanoic-Tyr-Ile-(6) aminohexanoic amide
- Category
- Nootropic & Cognitive
- Mechanism of action
- Hepatocyte growth factor (HGF) / c-Met receptor agonist that promotes synaptogenesis and dendritic spine density in hippocampal neurons.
- Targets
- HGF / c-Met signaling
- Indications under research or approved
- Research — Alzheimer's, cognitive enhancement
- Regulatory status (reference entry)
- Not FDA-approved
- Half-life
- Hours (oral, BBB penetrant)
- Sequence notes
- Modified angiotensin IV mimetic with non-natural N-hexanoyl and aminohexanoic acid groups for oral bioavailability.
- Molecular weight (Da)
- 433
- Originator / sponsor
- Originally M3 Biotechnology
- First reported
- 2012
Primary References
Explore research articles about Dihexa
This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.