# Dihexa

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Hepatocyte growth factor (HGF) / c-Met receptor agonist that promotes synaptogenesis and dendritic spine density in hippocampal neurons.

Reference facts

Also known asPNB-0408, N-hexanoic-Tyr-Ile-(6) aminohexanoic amideCategoryNootropic & CognitiveMechanism of actionHepatocyte growth factor (HGF) / c-Met receptor agonist that promotes synaptogenesis and dendritic spine density in hippocampal neurons.TargetsHGF / c-Met signalingIndications under research or approvedResearch — Alzheimer's, cognitive enhancementRegulatory status (reference entry)Not FDA-approvedHalf-lifeHours (oral, BBB penetrant)Sequence notesModified angiotensin IV mimetic with non-natural N-hexanoyl and aminohexanoic acid groups for oral bioavailability.Molecular weight (Da)433Originator / sponsorOriginally M3 BiotechnologyFirst reported2012
    Primary References

McCoy et al., J Neurochem 2013 (Dihexa)


    Explore research articles about Dihexa


    This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.

## Sources

- McCoy et al., J Neurochem 2013 (Dihexa): https://pubmed.ncbi.nlm.nih.gov/23145931/