Binds copper(II) with high affinity; modulates ~4,000 human genes related to wound healing, ECM remodeling, anti-inflammation, and DNA repair.
Reference facts
- Also known as
- Glycyl-L-histidyl-L-lysine
- Category
- Healing & Tissue Repair
- Mechanism of action
- Binds copper(II) with high affinity; modulates ~4,000 human genes related to wound healing, ECM remodeling, anti-inflammation, and DNA repair.
- Targets
- Cu²⁺ chelation, Decorin, integrin, MMP gene expression
- Indications under research or approved
- Cosmetic / wound healing (research)
- Regulatory status (reference entry)
- Cosmetic ingredient; not FDA-approved as drug
- Half-life
- minutes (rapid plasma clearance)
- Sequence
- GHK
- Sequence notes
- Tripeptide naturally present in plasma (~200 μg/L at age 20, declines with age).
- Molecular weight (Da)
- 340
- First reported
- 1973
- Origin
- Discovered by Loren Pickart in human plasma fraction.
Primary References
Explore research articles about GHK
This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.