Delivers copper to tissue; activates LOX cross-linking of collagen/elastin, modulates antioxidant gene expression and ECM remodeling.
Reference facts
- Also known as
- Copper Tripeptide-1, GHK-Copper
- Category
- Healing & Tissue Repair
- Mechanism of action
- Delivers copper to tissue; activates LOX cross-linking of collagen/elastin, modulates antioxidant gene expression and ECM remodeling.
- Targets
- Cu²⁺-dependent enzymes, Collagen synthesis
- Indications under research or approved
- Cosmetic anti-aging, hair regrowth, post-procedure skin healing
- Regulatory status (reference entry)
- Cosmetic; not FDA-approved as drug
- Half-life
- minutes (systemic); local action when topically applied
- Sequence
- GHK
- Sequence notes
- GHK tripeptide complexed 1:1 with Cu²⁺. The copper ion is essential for the regenerative signaling.
- Molecular weight (Da)
- 403
- First reported
- 1973
Primary References
Explore research articles about GHK-Cu
This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.