# GHK-Cu

Canonical source: https://retacompare.com/encyclopedia/ghk-cu

Delivers copper to tissue; activates LOX cross-linking of collagen/elastin, modulates antioxidant gene expression and ECM remodeling.

Reference facts

Also known asCopper Tripeptide-1, GHK-CopperCategoryHealing & Tissue RepairMechanism of actionDelivers copper to tissue; activates LOX cross-linking of collagen/elastin, modulates antioxidant gene expression and ECM remodeling.TargetsCu²⁺-dependent enzymes, Collagen synthesisIndications under research or approvedCosmetic anti-aging, hair regrowth, post-procedure skin healingRegulatory status (reference entry)Cosmetic; not FDA-approved as drugHalf-lifeminutes (systemic); local action when topically appliedSequenceGHKSequence notesGHK tripeptide complexed 1:1 with Cu²⁺. The copper ion is essential for the regenerative signaling.Molecular weight (Da)403First reported1973
    Primary References

Pickart, Biofactors 2008 (Copper peptide review)


    Explore research articles about GHK-Cu


    This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.

## Sources

- Pickart, Biofactors 2008 (Copper peptide review): https://pubmed.ncbi.nlm.nih.gov/19164049/