# GHK

Canonical source: https://retacompare.com/encyclopedia/ghk

Binds copper(II) with high affinity; modulates ~4,000 human genes related to wound healing, ECM remodeling, anti-inflammation, and DNA repair.

Reference facts

Also known asGlycyl-L-histidyl-L-lysineCategoryHealing & Tissue RepairMechanism of actionBinds copper(II) with high affinity; modulates ~4,000 human genes related to wound healing, ECM remodeling, anti-inflammation, and DNA repair.TargetsCu²⁺ chelation, Decorin, integrin, MMP gene expressionIndications under research or approvedCosmetic / wound healing (research)Regulatory status (reference entry)Cosmetic ingredient; not FDA-approved as drugHalf-lifeminutes (rapid plasma clearance)SequenceGHKSequence notesTripeptide naturally present in plasma (~200 μg/L at age 20, declines with age).Molecular weight (Da)340First reported1973OriginDiscovered by Loren Pickart in human plasma fraction.
    Primary References

Pickart & Margolina, IJMS 2018 (GHK review)


    Explore research articles about GHK


    This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.

## Sources

- Pickart & Margolina, IJMS 2018 (GHK review): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164349/