Major intracellular antioxidant; substrate for glutathione peroxidase, glutathione-S-transferase, and direct ROS quenching.
Reference facts
- Also known as
- γ-L-Glutamyl-L-cysteinyl-glycine
- Category
- Neuropeptide & Other
- Mechanism of action
- Major intracellular antioxidant; substrate for glutathione peroxidase, glutathione-S-transferase, and direct ROS quenching.
- Targets
- Multiple oxidative pathways
- Indications under research or approved
- Acetaminophen overdose (NAC precursor pathway); research in liver disease, COPD
- Regulatory status (reference entry)
- Dietary supplement; IV/inhaled forms compounded
- Half-life
- Minutes (intact in plasma); hours intracellularly
- Sequence notes
- Tripeptide γ-Glu-Cys-Gly. The γ-glutamyl bond between Glu and Cys is non-canonical and the tripeptide is therefore not represented by single-letter sequence.
- Molecular weight (Da)
- 307
- First reported
- 1888
Primary References
Explore research articles about Glutathione (GSH)
This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.