Native gonadotropin-releasing hormone. Pulsatile administration stimulates LH/FSH; continuous administration desensitizes the pituitary.
Reference facts
- Also known as
- GnRH, LHRH
- Category
- GnRH & Reproductive
- Mechanism of action
- Native gonadotropin-releasing hormone. Pulsatile administration stimulates LH/FSH; continuous administration desensitizes the pituitary.
- Targets
- GnRH receptor
- Indications under research or approved
- Diagnostic GnRH stimulation test; hypothalamic amenorrhea (pulsatile pump)
- Regulatory status (reference entry)
- FDA-approved (Factrel, Lutrepulse — partially discontinued)
- Half-life
- ~4 minutes
- Sequence
- QHWSYGLRPG
- Sequence notes
- Decapeptide pyroGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 (Q at position 1 = pyroglutamate).
- Molecular weight (Da)
- 1182
- First reported
- 1971
- Origin
- Sequenced by Andrew Schally and Roger Guillemin (Nobel Prize 1977).
Primary References
Explore research articles about Gonadorelin
This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.