# Gonadorelin

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Native gonadotropin-releasing hormone. Pulsatile administration stimulates LH/FSH; continuous administration desensitizes the pituitary.

Reference facts

Also known asGnRH, LHRHCategoryGnRH & ReproductiveMechanism of actionNative gonadotropin-releasing hormone. Pulsatile administration stimulates LH/FSH; continuous administration desensitizes the pituitary.TargetsGnRH receptorIndications under research or approvedDiagnostic GnRH stimulation test; hypothalamic amenorrhea (pulsatile pump)Regulatory status (reference entry)FDA-approved (Factrel, Lutrepulse — partially discontinued)Half-life~4 minutesSequenceQHWSYGLRPGSequence notesDecapeptide pyroGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 (Q at position 1 = pyroglutamate).Molecular weight (Da)1182First reported1971OriginSequenced by Andrew Schally and Roger Guillemin (Nobel Prize 1977).
    Primary References

Schally, Science 1971 (GnRH structure)


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    This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.

## Sources

- Schally, Science 1971 (GnRH structure): https://pubmed.ncbi.nlm.nih.gov/4937768/