Master regulator of iron homeostasis. Binds and triggers ferroportin internalization, blocking iron efflux from enterocytes and macrophages.
Reference facts
- Also known as
- LEAP-1
- Category
- Neuropeptide & Other
- Mechanism of action
- Master regulator of iron homeostasis. Binds and triggers ferroportin internalization, blocking iron efflux from enterocytes and macrophages.
- Targets
- Ferroportin
- Indications under research or approved
- Diagnostic biomarker; research in iron overload (hereditary hemochromatosis) and anemia of chronic disease
- Regulatory status (reference entry)
- Native not approved; analogs (Rusfertide) in trials
- Half-life
- ~6 hours
- Sequence
- DTHFPICIFCCGCCHRSKCGMCCKT
- Sequence notes
- 25-residue hepatic peptide with four disulfide bonds.
- Molecular weight (Da)
- 2789
- PDB accession
- 1M4F
- First reported
- 2000
Primary References
Explore research articles about Hepcidin
This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.