# Hepcidin

Canonical source: https://retacompare.com/encyclopedia/hepcidin

Master regulator of iron homeostasis. Binds and triggers ferroportin internalization, blocking iron efflux from enterocytes and macrophages.

Reference facts

Also known asLEAP-1CategoryNeuropeptide & OtherMechanism of actionMaster regulator of iron homeostasis. Binds and triggers ferroportin internalization, blocking iron efflux from enterocytes and macrophages.TargetsFerroportinIndications under research or approvedDiagnostic biomarker; research in iron overload (hereditary hemochromatosis) and anemia of chronic diseaseRegulatory status (reference entry)Native not approved; analogs (Rusfertide) in trialsHalf-life~6 hoursSequenceDTHFPICIFCCGCCHRSKCGMCCKTSequence notes25-residue hepatic peptide with four disulfide bonds.Molecular weight (Da)2789PDB accession1M4FFirst reported2000
    Primary References

Park et al., JBC 2001 (Hepcidin)


    Explore research articles about Hepcidin


    This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.

## Sources

- Park et al., JBC 2001 (Hepcidin): https://pubmed.ncbi.nlm.nih.gov/11035780/