Cytoprotective: binds Bax to prevent apoptosis; activates STAT3 via FPR2; protects neurons from amyloid-β toxicity in vitro.
Reference facts
- Also known as
- HN
- Category
- Mitochondrial & Cellular Longevity
- Mechanism of action
- Cytoprotective: binds Bax to prevent apoptosis; activates STAT3 via FPR2; protects neurons from amyloid-β toxicity in vitro.
- Targets
- Bax, FPR2, IGFBP-3
- Indications under research or approved
- Research — Alzheimer's, ischemia-reperfusion, longevity
- Regulatory status (reference entry)
- Not FDA-approved
- Half-life
- ~30 minutes (analogs longer)
- Sequence
- MAPRGFSCLLLLTSEIDLPVKRRA
- Sequence notes
- 24-residue mitochondrial-derived peptide encoded within the 16S rRNA gene of mtDNA.
- Molecular weight (Da)
- 2687
- First reported
- 2001
- Origin
- Identified by Hashimoto et al. while screening for factors that rescue neurons from APP-induced death.
Primary References
Explore research articles about Humanin
This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.