# Humanin

Canonical source: https://retacompare.com/encyclopedia/humanin

Cytoprotective: binds Bax to prevent apoptosis; activates STAT3 via FPR2; protects neurons from amyloid-β toxicity in vitro.

Reference facts

Also known asHNCategoryMitochondrial & Cellular LongevityMechanism of actionCytoprotective: binds Bax to prevent apoptosis; activates STAT3 via FPR2; protects neurons from amyloid-β toxicity in vitro.TargetsBax, FPR2, IGFBP-3Indications under research or approvedResearch — Alzheimer's, ischemia-reperfusion, longevityRegulatory status (reference entry)Not FDA-approvedHalf-life~30 minutes (analogs longer)SequenceMAPRGFSCLLLLTSEIDLPVKRRASequence notes24-residue mitochondrial-derived peptide encoded within the 16S rRNA gene of mtDNA.Molecular weight (Da)2687First reported2001OriginIdentified by Hashimoto et al. while screening for factors that rescue neurons from APP-induced death.
    Primary References

Hashimoto et al., PNAS 2001 (Humanin discovery)


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    This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.

## Sources

- Hashimoto et al., PNAS 2001 (Humanin discovery): https://pubmed.ncbi.nlm.nih.gov/11371653/