# Ipamorelin

Canonical source: https://retacompare.com/encyclopedia/ipamorelin

Selective ghrelin (GHS-R1a) receptor agonist. Drives a clean GH pulse without significant cortisol, prolactin or ACTH release.

Reference facts

Also known asNNC 26-1095CategoryGrowth Hormone & GhrelinMechanism of actionSelective ghrelin (GHS-R1a) receptor agonist. Drives a clean GH pulse without significant cortisol, prolactin or ACTH release.TargetsGHS-R1aIndications under research or approvedOff-label research (combined with CJC-1295 for synergistic GH pulse)Regulatory status (reference entry)Not FDA-approved (Phase 2 for post-operative ileus, discontinued)Half-life~2 hoursSequence notesPentapeptide H-Aib-His-D-2-Nal-D-Phe-Lys-NH2. Aib (α-aminoisobutyric acid), D-amino acids and C-terminal amide make it non-natural.Molecular weight (Da)712Originator / sponsorOriginally Novo NordiskFirst reported1998
    Primary References

Raun et al., Eur J Endocrinol 1998 (Ipamorelin)


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    This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.

## Sources

- Raun et al., Eur J Endocrinol 1998 (Ipamorelin): https://pubmed.ncbi.nlm.nih.gov/9849817/