Activates the GPR54 (KISS1R) receptor on hypothalamic GnRH neurons, driving GnRH and downstream LH/FSH release.
Reference facts
- Also known as
- Metastin (45-54), KP-10
- Category
- Sexual Health & MSH
- Mechanism of action
- Activates the GPR54 (KISS1R) receptor on hypothalamic GnRH neurons, driving GnRH and downstream LH/FSH release.
- Targets
- KISS1R / GPR54
- Indications under research or approved
- Research — hypothalamic amenorrhea, IVF trigger, male hypogonadism
- Regulatory status (reference entry)
- Investigational
- Half-life
- ~4 minutes
- Sequence
- YNWNSFGLRF
- Sequence notes
- Decapeptide C-terminal active fragment of human kisspeptin (full peptide 54 aa). C-terminal amide.
- Molecular weight (Da)
- 1302
- First reported
- 2001
Primary References
Explore research articles about Kisspeptin-10
This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.