# Kisspeptin-10

Canonical source: https://retacompare.com/encyclopedia/kisspeptin-10

Activates the GPR54 (KISS1R) receptor on hypothalamic GnRH neurons, driving GnRH and downstream LH/FSH release.

Reference facts

Also known asMetastin (45-54), KP-10CategorySexual Health & MSHMechanism of actionActivates the GPR54 (KISS1R) receptor on hypothalamic GnRH neurons, driving GnRH and downstream LH/FSH release.TargetsKISS1R / GPR54Indications under research or approvedResearch — hypothalamic amenorrhea, IVF trigger, male hypogonadismRegulatory status (reference entry)InvestigationalHalf-life~4 minutesSequenceYNWNSFGLRFSequence notesDecapeptide C-terminal active fragment of human kisspeptin (full peptide 54 aa). C-terminal amide.Molecular weight (Da)1302First reported2001
    Primary References

Skorupskaite et al., Hum Reprod Update 2014 (Kisspeptin)


    Explore research articles about Kisspeptin-10


    This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.

## Sources

- Skorupskaite et al., Hum Reprod Update 2014 (Kisspeptin): https://pubmed.ncbi.nlm.nih.gov/24615662/