Anti-inflammatory; suppresses NF-κB, IL-1β, TNF-α in gut and skin epithelial models without binding melanocortin receptors.
Reference facts
- Also known as
- α-MSH (11-13), Lys-Pro-Val
- Category
- Healing & Tissue Repair
- Mechanism of action
- Anti-inflammatory; suppresses NF-κB, IL-1β, TNF-α in gut and skin epithelial models without binding melanocortin receptors.
- Targets
- NF-κB pathway
- Indications under research or approved
- Research — IBD, atopic dermatitis
- Regulatory status (reference entry)
- Not FDA-approved
- Half-life
- minutes (oral peptide stable in gut)
- Sequence
- KPV
- Sequence notes
- C-terminal tripeptide of α-melanocyte-stimulating hormone, retains anti-inflammatory activity without melanogenesis.
- Molecular weight (Da)
- 343
- First reported
- 1982
Primary References
Explore research articles about KPV
This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.