# KPV

Canonical source: https://retacompare.com/encyclopedia/kpv

Anti-inflammatory; suppresses NF-κB, IL-1β, TNF-α in gut and skin epithelial models without binding melanocortin receptors.

Reference facts

Also known asα-MSH (11-13), Lys-Pro-ValCategoryHealing & Tissue RepairMechanism of actionAnti-inflammatory; suppresses NF-κB, IL-1β, TNF-α in gut and skin epithelial models without binding melanocortin receptors.TargetsNF-κB pathwayIndications under research or approvedResearch — IBD, atopic dermatitisRegulatory status (reference entry)Not FDA-approvedHalf-lifeminutes (oral peptide stable in gut)SequenceKPVSequence notesC-terminal tripeptide of α-melanocyte-stimulating hormone, retains anti-inflammatory activity without melanogenesis.Molecular weight (Da)343First reported1982
    Primary References

Dalmasso et al., Gastroenterology 2008 (KPV in colitis)


    Explore research articles about KPV


    This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.

## Sources

- Dalmasso et al., Gastroenterology 2008 (KPV in colitis): https://pubmed.ncbi.nlm.nih.gov/18166351/