# LL-37 (Antimicrobial)

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Cationic membrane-disrupting helix with broad-spectrum activity against Gram-positive, Gram-negative bacteria, fungi, viruses.

Reference facts

Also known asCathelicidin antimicrobial activityCategoryAntimicrobialMechanism of actionCationic membrane-disrupting helix with broad-spectrum activity against Gram-positive, Gram-negative bacteria, fungi, viruses.TargetsMicrobial membranesIndications under research or approvedResearchRegulatory status (reference entry)Not FDA-approvedHalf-lifeMinutesSequenceLLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTESSequence notesSame molecule as the immune entry; listed separately for indexing under antimicrobial peptides.Molecular weight (Da)4493PDB accession2K6OFirst reported1995
    Primary References

Vandamme et al., Cell Mol Immunol 2012


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    This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.

## Sources

- Vandamme et al., Cell Mol Immunol 2012: https://pubmed.ncbi.nlm.nih.gov/22648145/
