# LL-37

Canonical source: https://retacompare.com/encyclopedia/ll-37

Cationic alpha-helix that disrupts microbial membranes and modulates innate immunity (chemotaxis, angiogenesis, wound healing).

Reference facts

Also known asCathelicidin, hCAP18 (37 aa fragment)CategoryImmune ModulatorMechanism of actionCationic alpha-helix that disrupts microbial membranes and modulates innate immunity (chemotaxis, angiogenesis, wound healing).TargetsMicrobial membranes, FPR2/ALX receptorIndications under research or approvedResearch — antibiotic-resistant infections, wound healing, vitamin D innate immunityRegulatory status (reference entry)Not FDA-approvedHalf-lifeMinutes (rapidly degraded)SequenceLLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTESSequence notes37-residue active fragment of human cathelicidin antimicrobial peptide hCAP18; cleaved from the proform by proteinase 3.Molecular weight (Da)4493PDB accession2K6OFirst reported1995
    Primary References

Vandamme et al., Cell Mol Immunol 2012 (LL-37 review)


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    This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.

## Sources

- Vandamme et al., Cell Mol Immunol 2012 (LL-37 review): https://pubmed.ncbi.nlm.nih.gov/22648145/