Forms toroidal pores in microbial membranes, causing rapid lysis of bacteria, fungi, and protozoa.
Reference facts
- Also known as
- MAG-2
- Category
- Antimicrobial
- Mechanism of action
- Forms toroidal pores in microbial membranes, causing rapid lysis of bacteria, fungi, and protozoa.
- Targets
- Microbial membranes
- Indications under research or approved
- Research scaffold for antimicrobial peptide development
- Regulatory status (reference entry)
- Not FDA-approved (Pexiganan, a magainin analog, failed Phase 3)
- Half-life
- Minutes (rapidly degraded systemically)
- Sequence
- GIGKFLHSAKKFGKAFVGEIMNS
- Sequence notes
- 23-residue cationic α-helical peptide isolated from the skin of the African clawed frog (Xenopus laevis).
- Molecular weight (Da)
- 2466
- PDB accession
- 2MAG
- First reported
- 1987
- Origin
- Discovered by Michael Zasloff at NIH.
Primary References
Explore research articles about Magainin-2
This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.