# Magainin-2

Canonical source: https://retacompare.com/encyclopedia/magainin-2

Forms toroidal pores in microbial membranes, causing rapid lysis of bacteria, fungi, and protozoa.

Reference facts

Also known asMAG-2CategoryAntimicrobialMechanism of actionForms toroidal pores in microbial membranes, causing rapid lysis of bacteria, fungi, and protozoa.TargetsMicrobial membranesIndications under research or approvedResearch scaffold for antimicrobial peptide developmentRegulatory status (reference entry)Not FDA-approved (Pexiganan, a magainin analog, failed Phase 3)Half-lifeMinutes (rapidly degraded systemically)SequenceGIGKFLHSAKKFGKAFVGEIMNSSequence notes23-residue cationic α-helical peptide isolated from the skin of the African clawed frog (Xenopus laevis).Molecular weight (Da)2466PDB accession2MAGFirst reported1987OriginDiscovered by Michael Zasloff at NIH.
    Primary References

Zasloff, PNAS 1987 (Magainin discovery)


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    This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.

## Sources

- Zasloff, PNAS 1987 (Magainin discovery): https://pubmed.ncbi.nlm.nih.gov/3477799/