Stimulates fibroblast collagen I, III and fibronectin synthesis in vitro and in vivo on photoaged skin.
Reference facts
- Also known as
- Palmitoyl Pentapeptide-4, Pal-KTTKS
- Category
- Cosmetic & Skin
- Mechanism of action
- Stimulates fibroblast collagen I, III and fibronectin synthesis in vitro and in vivo on photoaged skin.
- Targets
- Fibroblast ECM gene expression
- Indications under research or approved
- Cosmetic anti-aging
- Regulatory status (reference entry)
- Cosmetic ingredient
- Half-life
- Topical, local
- Sequence
- KTTKS
- Sequence notes
- Pentapeptide N-acylated with palmitic acid for skin penetration; KTTKS is the cell-binding fragment of type I collagen.
- Molecular weight (Da)
- 802
- Originator / sponsor
- Sederma
- First reported
- 1993
Primary References
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This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.