# Matrixyl

Canonical source: https://retacompare.com/encyclopedia/matrixyl

Stimulates fibroblast collagen I, III and fibronectin synthesis in vitro and in vivo on photoaged skin.

Reference facts

Also known asPalmitoyl Pentapeptide-4, Pal-KTTKSCategoryCosmetic & SkinMechanism of actionStimulates fibroblast collagen I, III and fibronectin synthesis in vitro and in vivo on photoaged skin.TargetsFibroblast ECM gene expressionIndications under research or approvedCosmetic anti-agingRegulatory status (reference entry)Cosmetic ingredientHalf-lifeTopical, localSequenceKTTKSSequence notesPentapeptide N-acylated with palmitic acid for skin penetration; KTTKS is the cell-binding fragment of type I collagen.Molecular weight (Da)802Originator / sponsorSedermaFirst reported1993
    Primary References

Robinson et al., Int J Cosmet Sci 2005 (Matrixyl)


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    This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.

## Sources

- Robinson et al., Int J Cosmet Sci 2005 (Matrixyl): https://pubmed.ncbi.nlm.nih.gov/18492171/