Non-selective melanocortin agonist. Skin pigmentation via MC1R (eumelanin), libido via MC4R, appetite suppression via MC4R.
Reference facts
- Also known as
- MT-II
- Category
- Sexual Health & MSH
- Mechanism of action
- Non-selective melanocortin agonist. Skin pigmentation via MC1R (eumelanin), libido via MC4R, appetite suppression via MC4R.
- Targets
- MC1R, MC3R, MC4R, MC5R
- Indications under research or approved
- Research only; underground use for tanning and libido
- Regulatory status (reference entry)
- Not FDA-approved
- Half-life
- ~30 minutes (subcutaneous)
- Sequence notes
- Cyclic heptapeptide Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2 — MT-II differs from PT-141 by a C-terminal amide instead of a free carboxyl.
- Molecular weight (Da)
- 1024
- First reported
- 1989
- Origin
- Designed at the University of Arizona by Mac Hadley and Victor Hruby.
Primary References
Explore research articles about Melanotan II
This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.