# Melanotan II

Canonical source: https://retacompare.com/encyclopedia/melanotan-ii

Non-selective melanocortin agonist. Skin pigmentation via MC1R (eumelanin), libido via MC4R, appetite suppression via MC4R.

Reference facts

Also known asMT-IICategorySexual Health & MSHMechanism of actionNon-selective melanocortin agonist. Skin pigmentation via MC1R (eumelanin), libido via MC4R, appetite suppression via MC4R.TargetsMC1R, MC3R, MC4R, MC5RIndications under research or approvedResearch only; underground use for tanning and libidoRegulatory status (reference entry)Not FDA-approvedHalf-life~30 minutes (subcutaneous)Sequence notesCyclic heptapeptide Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2 — MT-II differs from PT-141 by a C-terminal amide instead of a free carboxyl.Molecular weight (Da)1024First reported1989OriginDesigned at the University of Arizona by Mac Hadley and Victor Hruby.
    Primary References

Hadley & Dorr, Peptides 2006 (Melanotan history)


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    This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.

## Sources

- Hadley & Dorr, Peptides 2006 (Melanotan history): https://pubmed.ncbi.nlm.nih.gov/16519975/