Activates AMPK in skeletal muscle and adipose; translocates to the nucleus under stress to regulate adaptive nuclear gene expression.
Reference facts
- Also known as
- Mitochondrial Open Reading Frame of the 12S rRNA-c
- Category
- Mitochondrial & Cellular Longevity
- Mechanism of action
- Activates AMPK in skeletal muscle and adipose; translocates to the nucleus under stress to regulate adaptive nuclear gene expression.
- Targets
- AMPK pathway, Folate metabolism (AICAR pool)
- Indications under research or approved
- Research — type 2 diabetes, obesity, sarcopenia, exercise mimicry
- Regulatory status (reference entry)
- Not FDA-approved
- Half-life
- ~3 hours (subcutaneous, native)
- Sequence
- MRWQEMGYIFYPRKLR
- Sequence notes
- 16-residue mitochondrial-derived peptide encoded within the 12S rRNA gene of mtDNA.
- Molecular weight (Da)
- 2174
- First reported
- 2015
- Origin
- Discovered by Pinchas Cohen and colleagues at USC.
Primary References
Explore research articles about MOTS-c
This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.