# MOTS-c

Canonical source: https://retacompare.com/encyclopedia/mots-c

Activates AMPK in skeletal muscle and adipose; translocates to the nucleus under stress to regulate adaptive nuclear gene expression.

Reference facts

Also known asMitochondrial Open Reading Frame of the 12S rRNA-cCategoryMitochondrial & Cellular LongevityMechanism of actionActivates AMPK in skeletal muscle and adipose; translocates to the nucleus under stress to regulate adaptive nuclear gene expression.TargetsAMPK pathway, Folate metabolism (AICAR pool)Indications under research or approvedResearch — type 2 diabetes, obesity, sarcopenia, exercise mimicryRegulatory status (reference entry)Not FDA-approvedHalf-life~3 hours (subcutaneous, native)SequenceMRWQEMGYIFYPRKLRSequence notes16-residue mitochondrial-derived peptide encoded within the 12S rRNA gene of mtDNA.Molecular weight (Da)2174First reported2015OriginDiscovered by Pinchas Cohen and colleagues at USC.
    Primary References

Lee et al., Cell Metab 2015 (MOTS-c discovery)

Reynolds et al., Nat Commun 2021 (MOTS-c exercise)


    Explore research articles about MOTS-c


    This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.

## Sources

- Lee et al., Cell Metab 2015 (MOTS-c discovery): https://pubmed.ncbi.nlm.nih.gov/25738459/
- Reynolds et al., Nat Commun 2021 (MOTS-c exercise): https://www.nature.com/articles/s41467-020-20790-0