# Oxyntomodulin

Canonical source: https://retacompare.com/encyclopedia/oxyntomodulin

Native dual incretin/glucagon hormone — template for synthetic dual agonists like Cotadutide and Mazdutide.

Reference facts

Also known asOXMCategoryGLP-1 & MetabolicMechanism of actionNative dual incretin/glucagon hormone — template for synthetic dual agonists like Cotadutide and Mazdutide.TargetsGLP-1R, GCGRIndications under research or approvedObesity (research)Regulatory status (reference entry)InvestigationalHalf-life~12 minutesSequenceHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNRNNIASequence notes37-residue native dual GLP-1 / glucagon receptor agonist; proglucagon-derived gut hormone.Molecular weight (Da)4448First reported1983
    Primary References

Wynne et al., Diabetes 2005 (OXM weight loss)


    Explore research articles about Oxyntomodulin


    This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.

## Sources

- Wynne et al., Diabetes 2005 (OXM weight loss): https://pubmed.ncbi.nlm.nih.gov/16306356/