Guanylate cyclase-C agonist (uroguanylin-like, pH-sensitive activity in proximal small intestine).
Reference facts
- Also known as
- Trulance
- Category
- Gastrointestinal
- Mechanism of action
- Guanylate cyclase-C agonist (uroguanylin-like, pH-sensitive activity in proximal small intestine).
- Targets
- GC-C receptor
- Indications under research or approved
- Chronic idiopathic constipation, IBS-C
- Regulatory status (reference entry)
- FDA-approved (2017)
- Half-life
- Negligible systemic absorption
- Sequence
- NDECELCVNVACTGCL
- Sequence notes
- 16-residue uroguanylin analog with two disulfide bonds; oral, gut-restricted.
- Molecular weight (Da)
- 1682
- Originator / sponsor
- Salix / Bausch Health
- First reported
- 2010
Primary References
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This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.