# Plecanatide

Canonical source: https://retacompare.com/encyclopedia/plecanatide

Guanylate cyclase-C agonist (uroguanylin-like, pH-sensitive activity in proximal small intestine).

Reference facts

Also known asTrulanceCategoryGastrointestinalMechanism of actionGuanylate cyclase-C agonist (uroguanylin-like, pH-sensitive activity in proximal small intestine).TargetsGC-C receptorIndications under research or approvedChronic idiopathic constipation, IBS-CRegulatory status (reference entry)FDA-approved (2017)Half-lifeNegligible systemic absorptionSequenceNDECELCVNVACTGCLSequence notes16-residue uroguanylin analog with two disulfide bonds; oral, gut-restricted.Molecular weight (Da)1682Originator / sponsorSalix / Bausch HealthFirst reported2010
    Primary References

Trulance FDA label


    Explore research articles about Plecanatide


    This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.

## Sources

- Trulance FDA label: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/208745s000lbl.pdf