# PYY 3-36

Canonical source: https://retacompare.com/encyclopedia/pyy-3-36

Selective Y2 receptor agonist in the arcuate nucleus, suppressing appetite via NPY neuron inhibition.

Reference facts

Also known asPeptide YY (3-36)CategoryGLP-1 & MetabolicMechanism of actionSelective Y2 receptor agonist in the arcuate nucleus, suppressing appetite via NPY neuron inhibition.TargetsY2 receptorIndications under research or approvedObesity (research; native peptide and long-acting analogs)Regulatory status (reference entry)InvestigationalHalf-life~10 minutes (native); analogs extend to daysSequenceIKPEAPGEDASPEELNRYYASLRHYLNLVTRQRYSequence notes34-residue gut-derived satiety peptide; a DPP-4 cleavage product of PYY 1-36.Molecular weight (Da)4050PDB accession2DEZOriginator / sponsorNovo Nordisk and others (analogs)First reported1982
    Primary References

Batterham et al., Nature 2002 (PYY satiety)


    Explore research articles about PYY 3-36


    This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.

## Sources

- Batterham et al., Nature 2002 (PYY satiety): https://pubmed.ncbi.nlm.nih.gov/12181570/