# Semax

Canonical source: https://retacompare.com/encyclopedia/semax

Increases BDNF and NGF in hippocampus; activates dopaminergic and serotonergic systems; melanocortin receptor activity.

Reference facts

Also known asMEHFPGP, ACTH (4-7) Pro-Gly-ProCategoryNootropic & CognitiveMechanism of actionIncreases BDNF and NGF in hippocampus; activates dopaminergic and serotonergic systems; melanocortin receptor activity.TargetsBDNF/NGF up-regulation, Melanocortin receptorsIndications under research or approvedApproved Russia (ischemic stroke, cognitive disorders); not US-approvedRegulatory status (reference entry)Not FDA-approvedHalf-life~30 minutes (intranasal)SequenceMEHFPGPSequence notesHeptapeptide. ACTH (4-7) fragment Met-Glu-His-Phe extended with the proline-glycine-proline tail used in Russian peptide design to resist enzymatic degradation.Molecular weight (Da)813First reported1981
    Primary References

Glazova et al., Front Pharmacol 2018 (Semax neuroprotection)


    Explore research articles about Semax


    This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.

## Sources

- Glazova et al., Front Pharmacol 2018 (Semax neuroprotection): https://pubmed.ncbi.nlm.nih.gov/29867500/