Activates the neurokinin-1 (NK1) receptor — pro-inflammatory, nociceptive transmission.
Reference facts
- Also known as
- SP, Neurokinin 1 ligand
- Category
- Neuropeptide & Other
- Mechanism of action
- Activates the neurokinin-1 (NK1) receptor — pro-inflammatory, nociceptive transmission.
- Targets
- NK1 receptor
- Indications under research or approved
- Research target (NK1 antagonists like Aprepitant are antiemetic drugs)
- Regulatory status (reference entry)
- Native peptide not approved; antagonists are
- Half-life
- Minutes
- Sequence
- RPKPQQFFGLM
- Sequence notes
- Undecapeptide with C-terminal amide; member of the tachykinin family.
- Molecular weight (Da)
- 1347
- First reported
- 1931
- Origin
- Identified by von Euler and Gaddum in horse brain and intestine extracts.
Primary References
Explore research articles about Substance P
This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.