# Substance P

Canonical source: https://retacompare.com/encyclopedia/substance-p

Activates the neurokinin-1 (NK1) receptor — pro-inflammatory, nociceptive transmission.

Reference facts

Also known asSP, Neurokinin 1 ligandCategoryNeuropeptide & OtherMechanism of actionActivates the neurokinin-1 (NK1) receptor — pro-inflammatory, nociceptive transmission.TargetsNK1 receptorIndications under research or approvedResearch target (NK1 antagonists like Aprepitant are antiemetic drugs)Regulatory status (reference entry)Native peptide not approved; antagonists areHalf-lifeMinutesSequenceRPKPQQFFGLMSequence notesUndecapeptide with C-terminal amide; member of the tachykinin family.Molecular weight (Da)1347First reported1931OriginIdentified by von Euler and Gaddum in horse brain and intestine extracts.
    Primary References

Steinhoff et al., Physiol Rev 2014 (NK1)


    Explore research articles about Substance P


    This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.

## Sources

- Steinhoff et al., Physiol Rev 2014 (NK1): https://pubmed.ncbi.nlm.nih.gov/24987005/