Binds G-actin and influences cell migration, angiogenesis, fibroblast and stem-cell recruitment; modulates inflammation in injury models.
Reference facts
- Also known as
- Thymosin Beta-4 fragment, TB4 Frag 17-23
- Category
- Healing & Tissue Repair
- Mechanism of action
- Binds G-actin and influences cell migration, angiogenesis, fibroblast and stem-cell recruitment; modulates inflammation in injury models.
- Targets
- G-actin, Angiogenic signaling
- Indications under research or approved
- Research only — soft tissue, tendon, corneal healing
- Regulatory status (reference entry)
- Not FDA-approved (full TB-4 is in clinical trials for dry eye and post-MI)
- Half-life
- ~2 hours (fragment); ~12 hours (full TB-4)
- Sequence
- LKKTETQ
- Sequence notes
- Synthetic peptide marketed as the active fragment of Thymosin Beta-4 (residues 17-23). Some research vials are labeled TB-500 but contain full-length TB-4 (43 aa).
- Molecular weight (Da)
- 889
- First reported
- 2000
Primary References
Explore research articles about TB-500
This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.