# TB-500

Canonical source: https://retacompare.com/encyclopedia/tb-500

Binds G-actin and influences cell migration, angiogenesis, fibroblast and stem-cell recruitment; modulates inflammation in injury models.

Reference facts

Also known asThymosin Beta-4 fragment, TB4 Frag 17-23CategoryHealing & Tissue RepairMechanism of actionBinds G-actin and influences cell migration, angiogenesis, fibroblast and stem-cell recruitment; modulates inflammation in injury models.TargetsG-actin, Angiogenic signalingIndications under research or approvedResearch only — soft tissue, tendon, corneal healingRegulatory status (reference entry)Not FDA-approved (full TB-4 is in clinical trials for dry eye and post-MI)Half-life~2 hours (fragment); ~12 hours (full TB-4)SequenceLKKTETQSequence notesSynthetic peptide marketed as the active fragment of Thymosin Beta-4 (residues 17-23). Some research vials are labeled TB-500 but contain full-length TB-4 (43 aa).Molecular weight (Da)889First reported2000
    Primary References

Goldstein, Ann NY Acad Sci 2007 (Thymosin Beta-4)


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    This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.

## Sources

- Goldstein, Ann NY Acad Sci 2007 (Thymosin Beta-4): https://pubmed.ncbi.nlm.nih.gov/17804524/