# Thymosin Alpha-1

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Activates Toll-like receptor 9 on plasmacytoid dendritic cells, restoring T-helper 1 immunity in immunocompromised states.

Reference facts

Also known asTα1, Zadaxin, ThymalfasinCategoryImmune ModulatorMechanism of actionActivates Toll-like receptor 9 on plasmacytoid dendritic cells, restoring T-helper 1 immunity in immunocompromised states.TargetsTLR9, T-cell maturationIndications under research or approvedHepatitis B (approved 35+ countries), Hepatitis C, sepsis, immune support in cancer (off-label/research)Regulatory status (reference entry)Not FDA-approved (orphan drug status; approved in EU, Asia)Half-life~2 hoursSequenceSDAAVDTSSEITTKDLKEKKEVVEEAENSequence notes28-residue acetylated peptide derived from prothymosin alpha; N-terminal acetylated.Molecular weight (Da)3108Originator / sponsorSciClone PharmaceuticalsFirst reported1972
    Primary References

Goldstein, Ann NY Acad Sci 2007 (Thymosin Alpha-1)


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    This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.

## Sources

- Goldstein, Ann NY Acad Sci 2007 (Thymosin Alpha-1): https://pubmed.ncbi.nlm.nih.gov/17804538/