# Thymosin Beta-4

Canonical source: https://retacompare.com/encyclopedia/thymosin-beta-4

Sequesters G-actin (1:1 stoichiometry), regulating cytoskeletal dynamics; promotes endothelial cell migration, angiogenesis, anti-inflammation.

Reference facts

Also known asTB-4, Tβ4CategoryHealing & Tissue RepairMechanism of actionSequesters G-actin (1:1 stoichiometry), regulating cytoskeletal dynamics; promotes endothelial cell migration, angiogenesis, anti-inflammation.TargetsG-actin, Multiple cytokine pathwaysIndications under research or approvedDry eye disease (RGN-259 Phase 3), Cardiac repair, wound healing (clinical trials)Regulatory status (reference entry)InvestigationalHalf-life~12 hoursSequenceSDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGESSequence notes43-residue ubiquitous actin-sequestering peptide; N-terminal acetylated in vivo.Molecular weight (Da)4963PDB accession1HJ0Originator / sponsorRegeneRx Biopharmaceuticals (RGN-259)First reported1981
    Primary References

Sosne et al., Expert Opin Biol Ther 2015 (TB-4 in dry eye)


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    This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.

## Sources

- Sosne et al., Expert Opin Biol Ther 2015 (TB-4 in dry eye): https://pubmed.ncbi.nlm.nih.gov/26211722/