Activates the TRH receptor on pituitary thyrotrophs and lactotrophs, releasing TSH and prolactin.
Reference facts
- Also known as
- Protirelin, Thyrel TRH
- Category
- Neuropeptide & Other
- Mechanism of action
- Activates the TRH receptor on pituitary thyrotrophs and lactotrophs, releasing TSH and prolactin.
- Targets
- TRHR
- Indications under research or approved
- Diagnostic — pituitary TSH stimulation test (legacy)
- Regulatory status (reference entry)
- FDA-approved (Thyrel TRH; mostly historical)
- Half-life
- ~5 minutes
- Sequence notes
- Tripeptide pyroGlu-His-Pro-NH2.
- Molecular weight (Da)
- 362
- First reported
- 1969
- Origin
- First hypothalamic-releasing hormone identified — by Roger Guillemin and Andrew Schally (Nobel Prize 1977).
Primary References
Explore research articles about Thyrotropin-Releasing Hormone (TRH)
This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.