# Thyrotropin-Releasing Hormone (TRH)

Canonical source: https://retacompare.com/encyclopedia/trh

Activates the TRH receptor on pituitary thyrotrophs and lactotrophs, releasing TSH and prolactin.

Reference facts

Also known asProtirelin, Thyrel TRHCategoryNeuropeptide & OtherMechanism of actionActivates the TRH receptor on pituitary thyrotrophs and lactotrophs, releasing TSH and prolactin.TargetsTRHRIndications under research or approvedDiagnostic — pituitary TSH stimulation test (legacy)Regulatory status (reference entry)FDA-approved (Thyrel TRH; mostly historical)Half-life~5 minutesSequence notesTripeptide pyroGlu-His-Pro-NH2.Molecular weight (Da)362First reported1969OriginFirst hypothalamic-releasing hormone identified — by Roger Guillemin and Andrew Schally (Nobel Prize 1977).
    Primary References

Guillemin, Science 1978 (Hypothalamic factors)


    Explore research articles about Thyrotropin-Releasing Hormone (TRH)


    This is an educational reference, not medical advice. Research findings do not establish safety or efficacy for self-administration. Consult the primary sources for study populations, limitations, and current regulatory status.

## Sources

- Guillemin, Science 1978 (Hypothalamic factors): https://pubmed.ncbi.nlm.nih.gov/100747/